Jennifer Weiser

Assistant Professor of Chemical Engineering

ChE 474: Drug Formulation and Delivery

Drug Formulation and Delivery

Class meeting times:

Tuesdays        4 – 6 PM in room 427

Thursdays       9 –  10 AM in room 427

Prerequisites:

ChE231 (Organic Chemistry I)

ChE342 (Heat and Mass Transfer)

Text and other requirements

Recommended textbook: “Drug Delivery: Engineering Principles for Drug Therapy” by W. Mark Saltzman

Course overview:

This course covers the fundamentals of drug formulation and drug delivery systems in the context of current therapeutics on the market and the process in which they were developed. Specific topics include traditional drug formulation, mechanisms and kinetics of pharmaceutical stability, controlled-release devices, transdermal delivery, intravenous delivery, oral drug delivery, pulmonary delivery, and targeted drug delivery. The course is designed to cover specific drug delivery topics that are expanded upon with student driven discussions of primary literature assigned by the professor.

Course Objectives

  1. To understand the underlying physical, chemical, and engineering principles that form the foundation of a wide range of drug delivery systems.
  2. To critically read, understand, and evaluate the primary drug delivery literature.
  3. To clearly present the concepts of specific drug delivery systems in a verbal format.

 Course topics include, but are not limited to and may be subject to change:

  • Pharmaceutical formulation
    • Small molecule formulation and stability
    • Solid state chemistry
    • Macromolecule stabilization
  • Polymer chemistry
    • Synthesis fundamentals
  • Transdermal drug delivery
  • Controlled release devices
    • Bioerodible, stimuli-sensitive, matrix
  • Intravenous drug delivery
    • Targeted drug delivery, PEGylation, gene therapy
  • Oral drug delivery
  • Lung/mucosal drug delivery
  • Intellectual property/patents