Publications
A BioBrick compatible strategy for genetic modification of plants. Boyle PM, Burrill DR, Inniss MC, Agapakis CM, Deardon A, Dewerd JG, Gedeon MA, Quinn JY, Paull ML, Raman AM, Theilmann MR, Wang L, Winn JC, Medvedik O, Schellenberg K, Haynes KA, Viel A, Brenner TJ, Church GM, Shah JV, Silver PA. Journal of Biological Engineering. Jun 20;6(1):8. (2012).
MSN2 and MSN4 link calorie restriction and TOR to sirtuin-mediated lifespan extension in Saccharomyces cerevisiae. Medvedik, O., Lamming, D.W., Kim, K.D., Sinclair, D.A.. PLoS Biology. Oct 2; 5(10):e261. (2007).
Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes. Milne JC, Lambert PD, Schenk S, Carney DP, Smith JJ, Gagne DJ, Jin L, Boss O, Perni RB, Vu CB, Bemis JE, Xie R, Disch JS, Ng PY, Nunes JJ, Lynch AV, Yang H, Galonek H, Israelian K, Choy W, Iffland A, Lavu S, Medvedik O, Sinclair DA, Olefsky JM, Jirousek MR, Elliott PJ, Westphal CH. Nature. Nov 29; 450(7170) pp712-6. (2007).
HST2 mediates SIR2-independent life-span extension by calorie restriction. Lamming, D. W., Latorre-Esteves, M., Medvedik, O., Wong, S. N., Tsang, F. A., Wang, C., Lin, S. J., Sinclair, D. A. Science. Sep 16; 309(5742) pp1861-4 (2005).
Nicotinamide and PNC1 govern lifespan extension by calorie restriction in Saccharomyces cerevisiae. Anderson, R. M., Bitterman, K. J., Wood, J. G., Medvedik, O. Sinclair, D. A. Nature. 423:6936 pp181-5 (2003).
Yeast life-span extension by calorie restriction is independent of NAD fluctuation. Anderson, R. M., Latorre-Esteves, M., Neves, A. R., Lavu, S., Medvedik, O., Taylor, C.,Howitz, K. T., Santos, H., Sinclair, D. A. Science. 302:5653 pp2124-6. (2003).
Manipulation of a nuclear NAD+ salvage pathway delays aging without altering steady-state NAD+ levels. Anderson, R. M., Bitterman, K. J.,Wood, J. G., Medvedik, O., Cohen, H., Lin, S. S., Manchester, J. K., Gordon, J. I., Sinclair, D. A. Journal of Biological Chemistry. 277:21 pp18881-90 (2002).
Longevity regulation in Saccharomyces cerevisiae: linking metabolism, genome stability, and heterochromatin. Bitterman, K. J., Medvedik, O. and Sinclair, D.A. Microbiological and Molecular Biology Reviews. 67:3 pp376-99 (2003). (Review)